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Document 3057
DOCN M94A3057
TI Immunological markers indicating the AIDS evolution.
DT 9412
AU Jauregui Rueda H; Balbaryski J; del Castillo M; Monticelli A; L.I.C.
Laboratory Buenos Aires, Argentina.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):163 (abstract no. PB0079). Unique
Identifier : AIDSLINE ICA10/94369518
AB OBJECTIVE: 1) To evaluate four immunological markers in HIV infected
patients classificated according to the CDC classification, April 1992.
2) To determine if some of the studied markers be of more predictive
value in the progression of the infection. 3) The relationship between
markers and mortality. METHODS: The records of patients with HIV
infection attending the L.I.C. LABORATORY, Buenos Aires, Argentina were
reviewed from January'92 to December'93. It was studied CD4+ linphocytes
count, B2 microglobuline, Agp24 and the level of IgA in 34 patients (31
male, 3 female; average age: 30 years old). The patients were
classificated according to the CDC classification. RESULTS: TABULAR
DATA, SEE ABSTRACT VOLUME. DISCUSSION AND CONCLUSIONS: 1 GROUP 1 (44%)
did not modify his stage A1A2, presenting normal values of CD4+ abs,
B2microglobuline, IgA level, and Agp24 not reactive. GROUP 2 (12%) made
a progress of the infection-disease from A1A2-B1B2-C1C2 with a
continuous decrease of CD4+ count, increase of B2microglobuline and IgA
level, and discontinuous reactivity of Agp24. GROUP 3 (44%) made a
progress of infection-disease to stage C3 where the CD4+ count decreased
below 50 cell/mm3, a major increasement of B2microglobuline and IgA
level, and reactive Agp24. 2) Linphocytes CD4+ count showed the best
correlation with the progression of the infection. 3) In GROUP 3 the 27%
of the patients died, not presenting any correlation between the
parameter and the mortality date.
DE beta 2-Microglobulin/METABOLISM Acquired Immunodeficiency
Syndrome/CLASSIFICATION/*DIAGNOSIS/ IMMUNOLOGY Adult Argentina
Biological Markers/*BLOOD Female Follow-Up Studies Human HIV Core
Protein p24/BLOOD HIV Infections/CLASSIFICATION/*DIAGNOSIS/IMMUNOLOGY
IgA/BLOOD Leukocyte Count Male T4 Lymphocytes/IMMUNOLOGY MEETING
ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).